Abstract: The Weizhou syncline, located in the fold-thrust belt on the western margin of the Ordos Basin, represents a typical medium-to-high rank and multi-seam coalbed methane (CBM) enrichment zone. Based on core and testing data from three parameter wells, this study systematically investigates the gas-bearing characteristics, adsorption behavior, recoverable potential, and feasibility of multi-seam co-production. The results show that the air-dry gas content of coal seams generally ranges from 10 to 25 m³/t, and increases linearly with burial depth, with the 12#-19# seams exhibiting the highest values (>16 m³/t). Gas saturation ranges from 41.6 % to 91.1 %, and the middle-lower seams are generally in a high-saturation state. According to the sensitive, inflection, and initiation pressure nodes derived from the Langmuir adsorption equation, most coal seams fall within the rapid or sensitive desorption stages. The average theoretical recoverable gas content is approximately 5.0 m³/t, with an average recovery factor of 34.6 %, indicating high production potential. A coupling model of “desorption ratio-liquid level-production seam combination” was established, and the liquid-level consistency window was proposed as a quantitative criterion for evaluating multi-seam co-production. Guided by this model, multilayer differential-pressure co-production was conducted in Well A (seams 12#, 13#, 14#, and 15#). The well achieved a gas rate of 2 048 m³/d after 122 days of drainage and maintained stable production for over 100 days, verifying the effectiveness of liquid-level optimization and coordinated multi-seam production. These results provide theoretical and practical insights for efficient development of deep CBM reservoirs and multi-layer cooperative exploitation along the western margin of the Ordos Basin.